Self Hypnosis and Clinical Hypnotherapy CDs & MP3 Downloads
High quality, professional and powerful hypnotherapy sessions!
Hypnotherapy To Stop Smoking
Molecular insight in the multifunctional activities of Withaferin A.
Herbal medicine which involves the use of plants for their medicinal value, dates as far back as the origin of mankind and demonstrates an array of applications including cardiovascular protection and anti-cancer activities, via antioxidant, anti-inflammatory and metabolic activities. Even today the popularity of medicinal herbs is still growing like in traditional medicines such as the Indian medicine, Ayurveda. One of the Ayurvedic medicinal plants is Withania somnifera Dunal, of which the important constituents are the withanolides. Among them, Withaferin A is one of the most bioactive compounds, exerting anti-inflammatory, pro-apoptotic but also anti-invasive and anti-angiogenic effects. In the context of modern pharmacology, a better insight in the underlying mechanism of the broad range of bioactivities exerted by Withaferin A is compulsory. Therefore, a lot of effort was made to explore the intracellular effects of Withaferin A and to characterize its target proteins. This review provides a decisive insight on the molecular basis of the health-promoting potential of Withaferin A.
Biochem Pharmacol. 2012 Sep 6. pii: S0006-2952(12)00583-7. doi: 10.1016/j.bcp.2012.08.027. Vanden Berghe W, Sabbe L, Kaileh M, Haegeman G, Heyninck K. Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, Proeftuinstraat 86, Gent, Belgium; Laboratory of Protein Science, Proteomics and Epigenetic Signalling (PPES), Department of Biomedical Sciences, University Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.
These are some of my favorite inspirational commitment quotes.
“Stay committed to your decisions, but stay flexible in your approach.” – Anthony Robbins
“There's a difference between interest and commitment. When you're interested in doing something, you do it only when circumstance permit. When you're committed to something, you accept no excuses, only results.” – Author Unknown
“Commitment unlocks the doors of imagination, allows vision, and gives us the "right stuff" to turn our dreams into reality.” – James Womack
“Desire is the key to motivation, but it's determination and...
Why worry about the things that we can’t control? But we do. Our superior brain allows us to anticipate. This is often to our advantage as it allows us to plan ahead and adapt to what we think may happen. However, when our imagination is out of control, this same tool will cause us misery. At that point it often needlessly activates our fight-flight mechanism. This in turn makes us unhappy and can eventually damage our immune system.
Unlike others, people who excessively worry have learned this behavior over time. It could even have been caused by a family member or friend who...
Unless you are one of very few lucky people, most likely the only way that you will ever be successful is to commit to taking the massive action required to achieve a goal. Star athletes, successful business people, and even those who have found the love of their lives realize that without commitment, nothing will ever be achieved. So, if this is such as well-established fact, why isn’t everyone a total success.
The answer to that question is that for too many people several of the areas of their brain, which should normally help them become masters of their universe, have enabled them to...
